The crucial weakness of all traditional measurement methods is the exclusively indirect determination of arterial stiffness via surrogate parameters such as pulse wave velocity (PWV), augmentation index (AIX), or flow-mediated dilation (FMD). These parameters are predominantly based on different methodological variants, all of which measure the pulse wave waveform at the upper arm, wrist, or finger. The surrogate parameters thus obtained then provide the measure of the elasticity or stiffness of the arteries.
However, due to the roundabout determination, the accuracy and traceability of the values fall by the wayside. In addition, these auxiliary parameters often report limitations in arterial distensibility, which is the most sensitive marker of arterial function, much too late, i.e., only when the first signs of disease are already apparent. In addition, the Doppler method, for example, which is often used in the context of pAVK screening, only ever records arterial pressure selectively, i.e. related to a single artery. This can lead to a false picture of the actual condition of the arteries — in the worst case, narrowings (stenoses) are overlooked. Thus, most of the conventional approaches to measurement data acquisition fall short of the task at hand, which is early diagnosis and prevention of cardiovascular disease.
In contrast to the previous, deficient diagnostic standard, individually tailored, model-based pulse wave analysis can be used to determine a whole range of new parameters that not only provide unrivaled detailed insight into the vascular status of patients but also offer added value in terms of effective prevention of cardiovascular events. These include pressures that can be measured directly in the model, particularly aortic pressure (cBP). More about the new parameters.